Action of parathyroid hormone in osteocytes
نویسندگان
چکیده
منابع مشابه
Understanding parathyroid hormone action.
In addition to regulating serum calcium and stimulating bone resorption, parathyroid hormone (PTH) is known to stimulate bone formation under certain conditions. The mechanisms behind this counterintuitive anabolic action are largely unknown. We have set out to identify PTH-regulated genes that might be responsible for each of these contrasting effects of the hormone. This article describes our...
متن کاملHypotensive action of parathyroid hormone in hypoparathyroid and hyperparathyroid rats.
Experimental and clinical data suggest an association between chronic hyperparathyroidism and hypertension, but acute infusion of parathyroid hormone causes vasodilation and hypotension. These observations imply that chronic and acute parathyroid states affect blood pressure through different mechanism(s), either by modification of vascular receptors or by an ionophoretic effect of parathyroid ...
متن کاملHypotensive Action of Parathyroid Hormone in Hypoparathyroid and Hyperparathyroid Rats
Experimental and clinical data suggest an association between chronic hyperparathyroidism and hypertension, but acute infusion of parathyroid hormone causes vasodilation and hypotension. These observations imply that chronic and acute parathyroid states affect blood pressure through different mechanism(s), either by modification of vascular receptors or by an ionophoretic effect of parathyroid ...
متن کاملHypotensive action of parathyroid hormone preparations on rats and dogs.
Bovine parathyroid extract and two commercial preparations containing the first 34 amino acids of synthetic bovine parathyroid hormone [bPTH-(1-34)]produced dose-related hypotension in anesthetized rats. Dogs were 10 times more sensitive to the two bPTH-(1-34) preparations than were rats. Propranolol, phentolamine, atropine, and promethazine did not affect the hypotensive action of bPTH-(1-34) ...
متن کاملThe Bipartite Action of Parathyroid Hormone-related Peptide on Cartilage
軟骨の研究は,骨 代謝研究のなかでも発生生物学的な アプロー チの視点から急速に進歩 してきた領域の1つ で ある。軟骨細胞の分化増殖,さ らに軟骨内骨化に対する 調節因子の研究は,基 礎的な細胞生物学ばか りでなく先 天異常を含めた遺伝子疾患の解明にも及び,そ の必要性 が再認識 されている(図1)。 そのなかで副甲状腺ホルモ ン関連ペ プチ ド(parathyroid hormone-related peptide: PTHrP)は,軟 骨の分化増殖に最 も重要な因子で あり,多 くの研究者によってその詳細が明 らかにされて いる。PTHrPに ついては,す でに1950年 代 にAlbright が,悪 性腫瘍から産生される副甲状腺ホルモン(PTH) 様の物質でありhumoral hypercalcemia of malignancy の高カルシウム血症の起因物質 としてその存...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2016
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2016.184